Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds

A compound selected from the formulas IIa, IIb

• wherein
• - - - - represents a single or a double bond, such that the ring containing the groups V and W is a phenyl, a furanyl or a thiophenyl ring;
• V is defined as —CR1═ or Q, and
• in case W is Q, then V is a single bond;
• W is defined as ═CR4— or Q, and
• in case V is Q, then W is a single bond;
• Q is O or S;
• Y is —(C═O)— or —(SO2)—;
• R1, R4 are each independently selected from the group consisting of H, F, Cl, Br, CN, CF3, C1-4-alkyl and C1-4-alkoxy;
• and
• R2, R3 are each independently selected from the group consisting of H, F, Cl, Br, CN, CF3, C1-4-alkyl and C1-4-alkoxy;
• or
• in case V is —CR1═ and W is ═CR4—, the substituents R2 and R3 may be linked together forming with the C-atoms to which they are attached to a C5-7-cycloalkyl, C5-7-cycloalkenyl or a phenyl group, wherein a cycloalkyl, cycloalkenyl or phenyl ring may be substituted with one or more substituents L2;
• or
• in case V is —CR1═ and W is ═CR4—, the substituents R1 and R2 may be linked together forming with the C-atoms to which they are attached to a C5-7-cycloalkyl, C5-7-cycloalkenyl or a phenyl group, wherein a cycloalkyl, cycloalkenyl or phenyl ring may be substituted with one or more substituents L2;
• R6 is H or C1-4-alkyl;
• L1 is each independently selected from the group consisting of C1-4-alkyl, C1-3-alkoxy, F, Cl, Br, CN, NO2 and CF3;
• L2, L3 is each independently selected from the group consisting of C1-4-alkyl, F, Cl, Br, CN and CF3;
• i is 0, 1, 2, 3, 4 or 5;
• k is 1, 2, 3, 4 or 5;
• or a pharmaceutically acceptable salt thereof.