Crystal forms of olanzapine and processes for their preparation
AssigneeKRKA, d.d. Novo mesto
InventorsBerta Kotar Jordan, Franc Vrecer, Marija Grcman
Life of this patent
Estimating the term…
Abstract
The invention relates to a process for the preparation of form I of olanzapine, crystallized from a solvent mixture which comprises 2-propanol, some pseudopolymorphic forms, namely solvates of olanzapine, anew polymorphic form A of olanzapine, and processes for the preparation thereof.
Claims28
A process for the preparation of form 1 of olanzapine, comprising the step of crystallizing olanzapine in a solvent mixture which comprises 2-propanol.
Acetonitrile/methylene chloride/water mixed solvate of olanzapine characterized by an x-ray powder diffraction pattern (2 theta) as follows:
- 8.76, 19.39, 20.12.
Acetonitrile/water mixed solvate of olanzapine characterized by an x-ray powder diffraction pattern (2 theta) as follows:
- 8.76, 9.10, 14.05, 19.37, 20.10, 24.55, 25.92, 27.96.
2-propanol solvate of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 8.74, 14.05, 19.38, 22.65, 23.03, 24.46, 25.92, 28.36.
Methylene chloride solvate IA of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 10.80, 14.25, 19.22, 22.78, 24.53.
Methylene chloride solvate IB of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 9.30, 10.80, 14.25, 14.98, 15.94, 19.23, 20.04.
Form A of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 11.52, 12.00, 13.35, 13.56, 14.21, 15.47, 16.69, 19.16, 20.25 20.69, 22.12, 24.33, 26.88, 27.13.
Dependencies are inferred from the claim text.