Bronchorelaxing compounds

A compound of formula (I) and its pharmaceutically acceptable acid addition salts

• wherein
• R1-R4 are, independent of each other H;
• C1-C6 alkyl;
• halogen;
• NR5R6, wherein R5 and R6 are, independent of each other, H, C1-C6 alkyl, C2-C6 acyl;
• OR7, wherein R7 is H, C1-C6 alkyl or C2-C6 acyl;
• CN;
• COR8, wherein R8 is H, C1-C6 alkyl or C1-C6 alkoxy;
• A is CHR9, wherein R9 is H, C1-C6 alkyl;
• n is 1-3;
• B is CHR10, wherein R10 is H, C1-C6 alkyl;
• m is 1 or 2;
• D is O or S;
• E is CR11R12 or NR13, wherein R11 and R12 are, independent of each other, H or C1-C6 alkyl and wherein R13 is H or C1-C6 alkyl;
• F is C1-C18 alkyl or C4-C7 cycloalkyl, which alkyl or cycloalkyl may be mono- or diunsaturated and/or substituted by alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, wherein, independent of each other, said C1-C18 alkyl, said C4-C7 cycloalkyl and said alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl substituent(s) is optionally further substituted by one to three substituents independently selected from F, Cl, Br;
• with the proviso that,
• if R1 and R2 are H, n is 2, m is 1, D is S, E is NH, F is 2-(4-chlorophenyl)ethyl or octyl, R3 and R4 are not both OH or OH and OCH3;
• if R1 and R4 are H, n is 1 to 3, m is 1, D is S, E is NH, F is 2-(4-chlorophenyl)ethyl or octyl, R2 and R3 are not both OH or OH and OCH3;
• if R1, R3 and R4 are H, n is 2, m is 1, D is O, E is 2-phenylethyl, R2 is not dimethylamino;
• if R1 and R4 are H, n is 2 or 3, m is 1, R2 and R3 are not both OCH3;
• no more than three of R1-R4 are H;
• n+m is from 2 to 4;
• F is not —(CH2)p-thienyl if p is 2 or 3;
• if R1 and R4 are H, m is 2, n is 1, D is O, E is CH2, F is CH3, R2 and R3 are not both OH.