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US 2006/0040915 A1Published application
Process for the preparation of cefdinir
OwnerYatendra Kumar, Mohan Prasad +3inventors
InventorsYatendra Kumar, Mohan Prasad, Ashok Prasad, Shailendra Singh, Neela Kumar
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Abstract
The present invention relates to a process for the preparation of cefdinir on an industrial scale.
Claims17
A process for the preparation of cefdinir of Formula I,
- which comprises removing a trityl protecting group in a cefdinir intermediate of formula II,
- wherein A is sulfuric acid or methanesulfonic acid, n=2 or 3, DMAC is N, N-dimethylacetamide and Ph is phenyl, in the presence or absence of an acid.
A process for the preparation of compound of Formula II
- wherein A is sulfuric acid or methanesulfonic acid, n=2 or 3, DMAC is N, N-dimethylacetamide and Ph is phenyl, which comprises reacting a reactive ester having the following formula P(iv),
- in which Ph represents phenyl, Z represents
- wherein R′ represents C1-C4 alkyl or phenyl, with a 3-cephem derivative having the following formula P(v),
- in a solvent comprising N, N-dimethylacetamide (DMAC) in the presence or absence of a base, and then adding sulfuric acid/methane sulfonic acid under cooling at about −10 to 0° C.
1 more element
A crystalline cefdinir intermediate having the following formula II:
- wherein A is sulfuric acid or methanesulfonic acid, n=2 or 3, DMAC is N, N-dimethylacetamide and Ph is phenyl.
Dependencies are inferred from the claim text.