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US 2006/0040901 A1Published application
Derivatives of 1,3-cyclic propandiol phosphate and their action as cell stimulants
AssigneeYeda Research and Development Co. Ltd.
InventorMeir Shinitzky
Life of this patent
Estimating the term…
Abstract
The present invention discloses new cyclic glycerophosphates and cyclic popandiol phosphates and pharmaceutical compositions comprising said compounds for promoting neural activity such as neuronal outgrowth, nerve growth, prevention of nerve degeneration and nerve rescue.
Claims15
1-14. (canceled)
A compound of the following formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- n is 1;
- X is hydrogen, O—R, NH—R, NO2, or N—(C═O)—R;
- X′ is hydrogen or CH2OH;
- Y is O—R1, NH—R1;
- R is hydrogen, linear or branched alkyl, linear or branched acyl, substituted or non-substituted aryl or aralkyl residue;
- R1 is hydrogen, linear or branched alkyl, linear or branched acyl, substituted or non-substituted aryl, alkylcarboxy ester or alkyl-N—R2R3;
- R2 and R3 are independently hydrogen or an alkyl group;
- alkyl is an alkyl group having from 1 to 24 carbon atoms, preferably from 3 carbon atoms to 20 carbon atoms, most preferably from 5 carbon atoms to 15 carbon atoms;
- wherein acyl is an aliphatic saturated or unsaturated C1-C24 acyl group, preferably an acyl group having an even number of carbon atoms, and most preferably an acyl group derived from a natural fatty acid such as a saturated aliphatic acyl group or an unsaturated aliphatic acyl group;
- and
- aryl is a to a mono- or poly-carbocyclic aryl group, most preferably phenyl, optionally substituted by C1-C4-alkyl, halogen and/or hydroxy;
- provided that X and X′ cannot both be hydrogen;
- that when X is NH—R, where R is a linear or branched acyl, then Y is not OR1 where R1 is a 4-nitrophenyl;
- and that when X′ is CH2OH, then X is NH—R or NO2.
13 more elements
Dependencies are inferred from the claim text.