R(-)-11-hydroxyaporphine derivatives and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt or solvate thereof,
• wherein
• Y1, is C(O)—R3, C(O)—O—R3, C(O)—NR3R4, P(O)(OH)—O—R3, C(S)—R3, C(S)—O—R3,
• C(S)—NR3R4, or fatty acid acyl;
• X1 is H, F, Cl, Br, I, OH, OCH3, or OC(O)—R5;
• R1 is H, C1-4 alkyl, C2-4 alkenyl, or C2-4 alkynyl;
• R2 is H, CH3, or OCH3;
• each of R3 and R4 is, independently, selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, and C1-7 heteroalkyl, or R3 and R4 together form a heterocyclic ring containing at least one nitrogen atom;
• and
• R5 is c1-4 alkyl, c2-4 alkenyl, or c2-4 alkynyl.