A medicament for treating an autoimmune disease, comprising a treatment enhancing amount of a first active ingredient when in combination with a second active ingredient, wherein the first active ingredient is selected from the group consisting of bisphosphonic acids corresponding to general formula (I)
- wherein
- A1, A2, A3 and A4 are independently selected from the group consisting of hydrogen, substituted and unsubstituted alkyl, substituted and unsubstituted aryl, substituted and unsubstituted aralkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocyclic residues, metals of Groups I, II and III of the Periodic Table of the elements, and substituted and unsubstituted ammonium or ammonium compounds derived from ethylenediamine or amino acids,
- X is absent or is selected from the group consisting of alkylene, alkenylene and hydroxyalkylene,
- R1 and R2 are independently selected from the group consisting of H, OH, —NH2, substituted and unsubstituted acyl, substituted and unsubstituted alkyl, substituted and unsubstituted aryl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted aralkyl, substituted and unsubstituted heterocyclic residues, —SR3, Cl and —NR3R4,
- in which
- R3 and R4 are independently selected from the group consisting of H, OH, substituted and unsubstituted acyl, substituted and unsubstituted alkyl, substituted and unsubstituted aryl, substituted and unsubstituted aralkyl, substituted and unsubstituted cycloalkyl and substituted and unsubstituted heterocyclic residues, their pharmaceutically compatible salts, esters thereof, salts of the esters and compounds, which upon administration from the compounds according to formula (I) or their salts or esters as metabolites or catabolites,
- and a treatment enhancing amount of a second active ingredient when in combination with the first active ingredient, wherein said second active ingredient is at least one autoantigen specific for the autoimmune disease to be treated and selected from the group consisting of preparations or extracts from nervous system tissue, collagen, thyroglobulin or fragments thereof, acetylcholine receptor protein or fragments thereof, DNA, preparations or extracts from islet cells, human insulin or fragments of human insulin peptide chains, preparations or extracts from liver tissue, preparations or extracts from adrenal cortex tissue, preparations or extracts from skin tissue, preparations or extracts from muscle tissue, preparations or extracts from haemopoetic cell lines, preparations or extracts from heart tissue, preparations of eye lens proteins or parts thereof, S-antigens or parts thereof, preparations or extracts from gastric cells, preparations or extracts from parietal cells, intrinsic factor, and preparations or extracts from intestinal mucosa;
- and/or autoantigen-like specific for the autoimmune disease represented by at least one synthetic peptide having the function of an autoantigen
- and an excipient.