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AssigneeParingenix, Inc.
InventorThomas Kennedy
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A method and medicament for anticoagulating a patient with a sulfated polysaccharide mixture that demonstrates enhanced anti-inflammatory activity compared to anticoagulation with unfractionated heparin comprising various combinations of fully anticoagulant unfractionated heparin with 2-O desulfated heparin demonstrating reduced anticoagulant activity but enhanced anti-inflammatory actions. The medicament preferably is administered intravenously, by aerosolization or orally. Preferably, the 2-O desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline and distilled water. Additionally provided is a method of synthesizing 2-O desulfated heparin in commercially practical quantities for the formulation of an anticoagulant 2-O desulfated heparin and heparin mixture.
A method for producing an anticoagulant and antithrombotic heparin with enhanced anti-inflammatory activity by mixing 5 to 50 parts by weight of modified heparin demonstrating reduced anticoagulant function with 0 to 1 parts by weight of unmodified heparin to produce an anticoagulant and antithrombotic heparin that both prolongs parameters of coagulation as an anticoagulant and reduces inflammation.
A medicament for treating inflammation in a patient simultaneously in need of anticoagulant or antithrombotic therapy that is produced by mixing 5 to 50 parts by weight of modified heparin with reduced anticoagulant function with 0 to 1 parts by weight of unmodified heparin to produce an anticoagulant and antithrombotic heparin that both prolongs parameters of coagulation as an anticoagulant and reduces inflammation.
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