Modulation of peroxisome proliferator-activated receptors
OwnerRong-Hwa Lin, Lee-Ming Chuanginventors
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Abstract
A method of treating a peroxisome proliferators-activated receptors related disease by administering to a subject in need thereof an effective amount of a modulator of 15-keto prostaglandin-Δ13-reductase. Also disclosed are methods of identifying a compound for inhibiting activity of the reductase and of lowering blood glucose levels by administering to a subject an effective amount of a reductase inhibitor.
Claims21
A method of treating a peroxisome proliferator-activated receptors (PPAR) related disease, comprising administering to a subject in need thereof an effective amount of a modulator of 15-keto prostaglandin-Δ13-reductase.
A method of lowering blood glucose levels in a subject, comprising administering to the subject an effective amount of an inhibitor of 15-keto prostaglandin-Δ13-reductase.
A method of identifying a compound for inhibiting activity of 15-keto prostaglandin-Δ13-reductase, comprising providing a system containing 15-keto prostaglandin-Δ13-reductase, contacting a compound with the system, determining the activity of the 15-keto prostaglandin-Δ13-reductase, and comparing the activity with that obtained in the same manner except that the compound is absent.
Dependencies are inferred from the claim text.