Inhibitors and enhancers of uridine diphosphate-glucuronosyltransferase 2B (UGT2B)

A pharmaceutical composition capable of increasing a bio-availability of a drug, including:

• an active ingredient as an Uridine diphosphate (UDP )-glucuronosyltransferases 2B (UGT2B) inhibitor that is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group comprising:
• capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate and umbelliferone inhibitor;
• and
• a pharmaceutically acceptable inert ingredient.

A pharmaceutical composition capable of enhancing a clearance rate of a drug, including:

• an active ingredient as an Uridine diphosphate (UDP )-glucuronosyltransferases 2B (UGT2B) enhancer that is a compound in a free base form or a pharmaceutically acceptable salt form that is selected from the group of:
• nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin,, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, uteolin-7-glucoside, egosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, and trans-cinnamaldehyde;
• and
• a pharmaceutically acceptable inert ingredient.