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AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsMotoo Yamasaki, Masami Okabe, Toshiyuki Suzawa, Ken Kobayashi, Kumiko Maruyama
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The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.
A method for increasing the platelet counts of a patient with decreased platelet counts comprising administering an effective amount of a modified polypeptide having an amino acid sequence wherein the first amino acid, threonine is replaced by alanine, the third amino acid, leucine is replaced by threonine, the fourth amino acid, glycine is replaced by tyrosine, the fifth amino acid, proline is replaced by arginine and the seventeenth amino acid, cysteine is replaced by serine, respectively in SEQ ID NO:
The method according to claim 24, wherein the mercapto group is modified with
The method according to claim 24, wherein the guanidino group is modified with a polyalkylene glycol derivatives having the formula (VI):
Dependencies are inferred from the claim text.