XAF genes and polypeptides: methods and reagents for modulating apoptosis
AssigneeAegera Therapeutics, Inc.
InventorsRobert Korneluk, Katsuyuki Tamai, Peter Liston, Alexander MacKenzie
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Abstract
The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
Claims21
A method of treating a patient diagnosed as having a condition involving insufficient apoptosis, said method comprising providing said patient with a polypeptide, said polypeptide comprising at least 85% amino acid sequence identity to SEQ ID NO:2, 4, 10, or 12, or a fragment thereof, said polypeptide having XAF biological activity, said providing in an amount sufficient to increase apoptosis in a cell of said patient.
Dependencies are inferred from the claim text.