Bioprocesses enhanced by magnetic nanoparticles
AssigneeMassachusetts Institute of Technology
InventorsLev Bromberg, T. Hatton, I. Wang, Jin Yin, Bernat Olle
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AssigneeMassachusetts Institute of Technology
InventorsLev Bromberg, T. Hatton, I. Wang, Jin Yin, Bernat Olle
Estimating the term…
One aspect of the present invention relates to magnetic nanoparticles colloidally stabilized in aqueous milieu by association with an organic phase. The organic phase may be either a fluorinated polymer or an organic hydrocarbon bilayer, wherein the two layers are chemically bonded to each other. The stabilized particles are further non-toxic and provide useful enhancements in bioprocesses. Another aspect of the present invention relates to compositions comprising an oxygen-dissolving fluid vehicle and surface modified, nanometer-sized magnetic particles. The inventive compositions have utility in a wide range of applications, but are particularly suitable for use as recyclable oxygen carriers, separation and purification vehicles, and bioprocessing media, including fermentation processes.
A nanoparticle comprising an inorganic compound associated with an organic phase, wherein the organic phase is capable of reversibly solubilizing a gas.
A method of preparing nanoparticles comprising an inorganic compound incorporated within the interstices of a fluorine-containing polymer comprising:
A method of preparing nanoparticles comprising an inorganic compound associated with a hydrocarbon bilayer comprising a first hydrocarbon layer chemically bonded to a second hydrocarbon layer comprising:
A method of increasing the amount of gas transfer to a medium comprising introducing to the medium nanoparticles comprising an inorganic compound associated with an organic phase, wherein the organic phase is capable of reversibly solubilizing a gas.
A method of enhancing cell growth in fermentation processes comprising introducing to a fermentation medium comprising a cell culture nanoparticles comprising an inorganic compound associated with an organic phase, wherein the organic phase is capable of reversibly solubilizing oxygen, thereby increasing the amount of oxygen transfer to the fermentation medium.
Dependencies are inferred from the claim text.