Bioarray chip reaction apparatus and its manufacture
AssigneeAffymetrix, Inc.
InventorsDonald Besemer, Virginia Goss, James Winkler
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Abstract
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
Claims4
1-92. (canceled)
A method of aligning an array hybridization apparatus comprising:
- (a) providing a first substrate, second substrate and at least 2 standoffs;
- and (b) contacting the first substrate to the standoff to align the array hybridization apparatus.
A method of making an array hybridization apparatus with a standoff for alignment, comprising:
- (a) providing a first substrate opposite a second substrate;
- (b) interposing a standoff between a first substrate and a second substrate;
- (c) contacting the first substrate and second substrate to the standoff.
A method of making an array hybridization apparatus for aligning a gasket, comprising:
- (a) providing a first substrate;
- (b) attaching at least two standoffs to the first substrate;
- (c) using the standoff to align at least one gasket on the first substrate using the standoff and the gasket.
Dependencies are inferred from the claim text.