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US 2006/0040376 A1Published application
Guided mode resonant filter biosensor using a linear grating surface structure
AssigneeSRU Biosystems, Inc.
InventorsBrian Cunningham, Jane Pepper, Bo Lin, Peter Li, Jean Qiu, Homer Pien
Life of this patent
Estimating the term…
Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
Claims18
1-24. (canceled)
A biosensor comprising:
- (a) a one-dimensional grating surface structure comprised of a material having a low refractive index;
- (b) a high refractive index material layer that is applied on top of the low refractive index one-dimensional grating layer;
- and
- (c) one or more specific binding substances immobilized on a surface of the high refractive index layer opposite of the one-dimensional grating surface structure comprised of a material having a low refractive index;
- wherein the one or more specific binding substances are bound to their binding partners and wherein one or more specific binding substances and their binding partners are detection label-free,
- wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect.
3 more elements
(canceled)
A liquid-containing vessel comprising a biosensor as an internal surface, wherein the biosensor comprises:
- (a) a one-dimensional grating surface structure comprised of a material having a low refractive index;
- (b) a high refractive index material layer that is applied on top of the low refractive index one-dimensional grating layer;
- and
- (c) one or more specific binding substances immobilized on a surface of the high refractive index layer opposite of the one-dimensional grating surface structure comprised of a material having a low refractive index;
- wherein the one or more specific binding substances are bound to their binding partners and wherein one or more specific binding substances and their binding partners are detection label-free,
- wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect.
3 more elements
41-94. (canceled)
Dependencies are inferred from the claim text.