Adipocyte complement related protein homolog zacrp7
AssigneeZymoGenetics, Inc.
InventorsChristopher Piddington, Paul Sheppard
Life of this patent
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Abstract
The present invention relates to polynucleotide and polypeptide molecules for zacrp7, a novel member of the family of proteins bearing a collagen-like domain and a Clq domain. The polypeptides and polynucleotides encoding them, are involved in homo and heterotrimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp7 polypeptides.
Claims24
An isolated polynucleotide encoding a polypeptide comprising amino acid residues 154-303 of SEQ ID NO:2.
An isolated polynucleotide encoding a polypeptide comprising amino acid residues 15-153 of SEQ ID NO:2.
An isolated polynucleotide encoding a polypeptide comprising a sequence selected from the group consisting of:
- a) amino acid residues 52-153 of SEQ ID NO:2;
- b) amino acid residues 154-303 of SEQ ID NO:2;
- c) amino acid residues 52-303 of SEQ ID NO:2;
- d) amino acid residues 31-303 of SEQ ID NO:2;
- and
- e) amino acid residues 1-303 of SEQ ID NO:2.
An isolated polynucleotide encoding a fusion protein comprising a first portion and a second portion joined by a peptide bond, wherein said first portion is an isolated polypeptide comprising amino acid residues 154-303 of SEQ ID NO:2 or an isolated polypeptide comprising amino acid residues 52-153 of SEQ ID NO:2, and wherein said second portion comprises another polypeptide.
An isolated polynucleotide comprising a sequence selected from the group consisting of,
- a) nucleotides 1 to 909 of SEQ ID NO:1;
- b) nucleotides 91 to 909 of SEQ ID NO:1;
- c) nucleotides 154 to 909 of SEQ ID NO:1;
- d) nucleotides 460 to 909 of SEQ ID NO:1;
- and
- e) nucleotide sequences complementary to a), b), c), or d).
An expression vector comprising the following operably linked elements:
- a transcription promoter;
- a DNA segment encoding a polypeptide comprising amino acid residues 154-303 of SEQ ID NO:2;
- and
- a transcription terminator.
An expression vector comprising the following operably linked elements:
- a transcription promoter;
- a DNA segment encoding a polypeptide comprising amino acid residues 52-153 of SEQ ID NO:2;
- and
- a transcription terminator.
Dependencies are inferred from the claim text.