Rabconnectin-3-binding protein
AssigneeEisai Co., Ltd.
InventorsMasakazu Takeuchi, Yoshimi Takai
Life of this patent
Estimating the term…
Abstract
A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.
Claims6
1-22. (canceled)
A method of screening for a material that promotes or inhibits binding between a rabconnectin-3-binding protein and rabconnectin-3, comprising the steps of:
- contacting a rabconnectin-3-binding protein with rabconnectin-3 in the presence and absence of a candidate material, and
- determining whether the candidate material increases or decreases binding between the rabconnectin-3-binding protein and rabconnectin-3.
24-31. (canceled)
Dependencies are inferred from the claim text.