Human chemokine beta-9
AssigneeHuman Genome Sciences, Inc.
InventorsHaodong Li, Mark Adams
Life of this patent
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Abstract
Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.
Claims19
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 134 as set forth in SEQ ID NO:2;
- (b) a polynucleotide encoding the polypeptide comprising amino acid 24 to amino acid 134 as set forth in SEQ ID NO:2;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide which encodes the full length polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit NO:
- 75803;
- (b) a polynucleotide which encodes a mature polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit NO:
- 75803;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
Dependencies are inferred from the claim text.