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US 2006/0040308 A1Published application
Compounds and methods for the characterization of oligonucleotides
AssigneeIsis Pharmaceuticals, Inc.
InventorsDaniel Capaldi, Hans-Joachim Gaus, Claus Rentel, Philip Olsen, Christine Kurata, Quanlai Song
Life of this patent
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Abstract
The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides.
Claims17
A compound of Formula I, II or III:
- wherein
- each R1, R2, R3 and R4 is independently a 2′-O-, 3′-O-, or 5′-O-linked nucleoside optionally attached to solid support, a 2′-O-, 3′-O-, or 5′-O-linked oligonucleotide optionally attached to solid support, —NiPr2, —O(CH2)2CN, —OH or —SH, and
- each G is independently O or S.
A compound of Formula IV:
- wherein
- each R4, R5 and R6 is independently a 2′-O-, 3′-O-, or 5′-O-linked nucleoside optionally attached to solid support, or a 2′-O-, 3′-O-, or 5′-O-linked oligonucleotide optionally attached to solid support, and
- G is O or S.
A compound of Formula V:
- wherein
- R7 and R8 are independently a 2′-O-, 3′-O-, or 5′-O-linked nucleoside optionally attached to solid support, a 2′-O-, 3′-O-, or 5′-O-linked oligonucleotide optionally attached to solid support, —SH or —OH,
- each G is independently O or S, and
- R2′ is H, OH, O-rg wherein rg is a removable protecting group, or a 2′ substituent.
1 more element
Dependencies are inferred from the claim text.