Biallelic markers related to genes involved in drug metabolism
AssigneeSerono Genetics Institute S.A.
InventorsMarta Blumenfeld, Ilya Chumakov, Lydie Bougueleret, Annick Cohen-Akenine
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Abstract
The invention provides polynucleotides including biallelic markers derived from genes involved in the biotransformation of xenobiotics such as drugs and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
Claims8
A method of determining the genotype of an individual comprising the steps of:
- a) obtaining a biological sample containing a polynucleotide comprising the nucleotide sequence of SEQ ID NO:
- 13 from said individual;
- and
- b) determining the identity of a nucleotide at a biallelic marker of SEQ ID NO:
- 13 wherein said nucleotide determines said genotype of said individual.
An isolated polynucleotide comprising SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.