Method for detecting the risk of and for treatment of type 2 diabetes
AssigneeOy Jurilab Ltd
InventorsJukka Salonen, Ricardo Fuentes, Outi Kontkanen, Mia Pirskanen, Pekka Uimari
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Abstract
A role of the human EXT2 gene in metabolic conditions such as T2D is disclosed. Methods and test kits for diagnosis, T2D risk prediction and prediction of clinical course of a metabolic condition using biomarkers related to the EXT2 gene are disclosed. Novel methods for prevention and treatment of metabolic diseases based on EXT2 gene, polypeptides and EXT2 related pathways are also disclosed.
Claims63
A method for risk prediction, diagnosis or prognosis of a metabolic condition or trait in a subject comprising the steps of:
- a) providing a biological sample taken from the subject;
- b) assessing type and/or level of one or more biomarkers in said sample, wherein said biomarkers are associated to the exostoses 2 (EXT2) gene, to EXT2 expression or to EXT2 metabolic activity;
- and
- c) comparing the biomarker data from the subject to healthy and/or diseased controls to make risk prediction, diagnosis or prognosis of a metabolic condition or trait.
A method for preventing or treating a metabolic condition or trait in a subject comprising a therapy modulating EXT2 metabolic activity in said subject.
Dependencies are inferred from the claim text.