Prognostic tests for development of dermal stretch marks and implications for the preventive treatment thereof
AssigneesHuman Matrix Sciences, LLC, The Hospital for Sick Children
InventorsThomas Mitts, Felipe Jimenez, Aleksander Hinek
Life of this patent
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Abstract
Various methods of assessing the regenerative potential of dermal tissue in a patient may be determined and methods to determine the potential development of stretch marks in a patient are provided. Through the analysis of a series of dermal tissue samples, a method of monitoring the aging process of the dermal tissue of a patient is possible. Damaged or stretched marked skin may also be used in the development of various diagnostic therapies relating to the inducement of the extracellular matrix components of the skin due to the loss of elastic fibers generally found in stretch marked skin.
Claims16
A method of diagnosing the regenerative potential of dermal tissue in a patient comprising:
- establishing a baseline value for normal dermal tissue;
- obtaining a sample of dermal tissue from said patient;
- and
- comparing said sample of dermal tissue from the patient with the baseline value for normal dermal tissue to identify a quantitative difference between the sample and normal tissue.
A method of diagnosing the potential for the development of stretch marks in a patient comprising:
- establishing a baseline value for normal dermal tissue;
- obtaining a sample of dermal tissue from said patient;
- and
- comparing said sample of dermal tissue from the patient with the baseline value for normal dermal tissue to identify a quantitative difference between the sample and normal tissue.
A method of establishing a treatment protocol comprising determining the likelihood of stretch marks forming;
- pretreating the affected area to mitigate the occurrence of stretch marks.
A kit for determining the propensity for forming stretch marks comprising components to measure a value selected from the group consisting of:
- the DNA content of the fibroblasts in said dermal tissue;
- the extracellular matrix protein content of said dermal tissue;
- the connective tissue content of said dermal tissue;
- collagen content of said dermal tissue;
- fibrillin content of said dermal tissue;
- the rate of proliferation of fibroblasts in said dermal tissue;
- the rate of migration of fibroblasts in said dermal tissue;
- the rate of connective tissue synthesis in said dermal tissue;
- the rate of extracellular matrix protein by said fibroblasts;
- and a combination thereof.
Dependencies are inferred from the claim text.