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US 2006/0039870 A1Published application
Pulmonary delivery of enzymatic medical countermeasures
OwnerJeffrey Turnerinventor
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OwnerJeffrey Turnerinventor
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The present invention provides for non-invasive treatment of nerve agent poisoning by administering nerve agent neutralizing enzymes to the pulmonary epithelium of a subject, by inhalation, where they accumulate within the lungs. Localization of such enzymes in the pulmonary epithelium results in neutralization of the nerve agents at the lungs. As a result, nerve agents move by diffusion out of the blood through the pulmonary capillaries, duc to the organophosphorus nerve agents rapid diffusion across the cell membranes of the body via diffusion, down their concentration gradients. The present invention presents a practical method of administering nerve agent neutralizing enzymes, without requiring passage into the blood plasma, and without requiring blood plasma activity of the enzyme.
A method of treating nerve agent poisoning in a subject which method comprises providing an effective amount of a nerve agent neutralizing enzyme to pulmonary epithelium of the subject by inhalation.
A pharmaceutical dosage form for delivery of a nerve agent neutralizing enzyme to the pulmonary system of a mammal, the form comprising a therapeutically effective amount of a cholinesterase and a pharmaceutically acceptable carrier or diluent, wherein said dosage form is contained in an inhaler or nebulizer.
A pharmaceutical formulation for delivery of a cholinesterase to the pulmonary system of a mammal comprising cholincsterase particles having a diameter of about 0.01 μm to about 4 μm and a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.