Identification and use of growth hormone secretagogue receptor type 1A antagonists
AssigneeNovo Nordisk A/S
InventorsMaibritt Andersen, Birgit Hansen, Kirsten Raun, Soren Tullin, Lars Thim
Life of this patent
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Abstract
Compounds that are ligands for the growth hormone secretagogue receptor type 1A (GHS-R 1A), as well as pharmaceutically acceptable salts of such compounds, are useful for the manufacture of medicaments for the regulation of food intake.
Claims20
A method of identifying compositions for decreasing food intake comprising testing one or more compounds in an assay that is indicative of whether a compound acts as a growth hormone secretagogue receptor type 1A (GHS-R 1A) antagonist and testing the ability of any compound identified as a GHS-R 1A antagonist to decrease food intake in a subject.
A method of preparing a pharmaceutical composition comprising providing a compound that has been identified as a growth hormone secretagogue receptor type 1A (GHS-R 1A) antagonist and mixing an effective amount thereof with one or more pharmaceutically acceptable carriers or diluents.
A method of decreasing food intake in a subject comprising administering to the subject an effective amount of a growth hormone secretagogue receptor type 1A (GHS-R 1A) antagonist.
Dependencies are inferred from the claim text.