Enhanced thawing of biopharmaceutical solutions using oscillatory motion
AssigneeIntegrated Biosystems, Inc.
InventorRichard Wisniewski
Life of this patent
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Abstract
Disclosed are methods for thawing frozen biopharmaceutical solutions including providing a container that contains a biopharmaceutical solution, at least a portion of the biopharmaceutical solution being frozen, providing an oscillatory driver coupled to the biopharmaceutical solution; providing a heat flux into the biopharmaceutical solution; and inducing oscillatory motion of the biopharmaceutical solution via oscillatory motion of the oscillatory driver to accelerate thawing, compared to motionless thawing, of the portion of the biopharmaceutical solution that is frozen. Also disclosed are devices for thawing frozen biopharmaceutical solutions.
Claims17
A method for thawing frozen biopharmaceutical solutions comprising:
- providing a container that contains a biopharmaceutical solution, at least a portion of the biopharmaceutical solution being frozen,
- providing an oscillatory driver coupled to the biopharmaceutical solution;
- providing a heat flux into the biopharmaceutical solution;
- and
- inducing oscillatory motion of the biopharmaceutical solution via oscillatory motion of the oscillatory driver to accelerate thawing, compared to motionless thawing, of the portion of the biopharmaceutical solution that is frozen.
A device for accelerated thawing of a biopharmaceutical solution comprising
- a container configured to contain the biopharmaceutical solution, wherein at least a portion of the biopharmaceutical solution is frozen;
- a heating element, coupled to the container, that provides heat flux into the container;
- and
- an oscillatory driver capable of being coupled to the biopharmaceutical solution, for inducing oscillatory motion of the biopharmaceutical solution to accelerate thawing, compared to motionless thawing, of the portion of the biopharmaceutical solution that is frozen.
Dependencies are inferred from the claim text.