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AssigneeBio Array Solutions Ltd.
InventorsMichael Seul, Robert Danehy
Estimating the term…
Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.
A strategy for operating a registry offering access to genotyped prospective transfusion donors, for matching to a transfusion recipient of given genotype or phenotype, in a manner increasing the probability of having an acceptable donor for any recipient querying the registry while decreasing the total number of prospective donors to be typed, comprising:
A strategy for reducing the cost of genotyping of candidate donors and maximizing the probability of matching of candidate donors and recipients, comprising ranking the genetic markers which are associated with clinically significant events in order of severity of the event, and matching donors and recipients for only those markers which are associated with a severity greater than a threshold value.
A strategy for reducing the cost of genotyping of candidate donors and maximizing the matching of candidate donors and recipients, comprising:
A strategy of maximizing the probability of a positive clinical outcome of transfusion while limiting the total number of donors subjected to cross-matching with any recipient in order to obtain an acceptable cross-match, wherein
A system for reducing the incidence of allo-immunization in recipients transfused by samples obtained from member institutions, where the member institutions form a registry which retains a database of genotyped donors, and where member institutions each perform a number of transfusions to different recipients, comprising:
A method of virtual centralization of molecular diagnostics within a network of member institutions, comprising:
A method of increasing the fraction of repeat donations by incentivizing selected genotyped donors, wherein said incentives include extending authorization to said donors having particular genotypes for preferential access, as against other recipients, to the registry in the event said donors require transfusion.
Dependencies are inferred from the claim text.