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US 2006/0008849 A1Published application
Methods for measuring chloride channel conductivity
OwnerWeimin Tang, Mary Wildeyinventors
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Abstract
The invention provides non-radioactive methods to assay for functional chloride channels. The methods colorimetrically detect the amount of iodide conducted by a chloride channel. They can be easily adapted for high throughput assays or screenings.
Claims26
A method for measuring chloride channel conductivity, comprising the steps of:
- a) contacting a chloride channel with iodide;
- and
- b) calorimetrically detecting the amount of iodide conducted by the chloride channel.
A method for determining an effect of a test compound on the conductivity of a chloride channel, comprising the steps of
- a) contacting the chloride channel with the test compound and iodide;
- b) calorimetrically detecting the amount of iodide conducted by the chloride channel;
- and
- c) comparing the amount of iodide detected in step b) with that of a control wherein the chloride channel is not contacted with the test compound.
1 more element
Dependencies are inferred from the claim text.