Compounds for inhibiting insulin secretion and methods related thereto

A compound having the structure:

• or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein:
• X is —S(O)q—, —O—, —N(R)— or —C(R)(R′)—;
• m is 0 or 1;
• n is 0, 1 or 2;
• q is 0, 1 or 2;
• W1 and W2 each represent an optional substituent, wherein W1 and W2 are the same or different and independently halogen, nitro, or lower alkyl;
• R and R′ are the same or different and independently alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl or substituted arylalkyl,
• or R and R′ taken together with the carbon atom to which they are bonded form a carbocycle, substituted carbocycle, heterocycle or substituted heterocycle;
• R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl or substituted heteroaryl;
• R2 is hydrogen, nitro, —OR2a, —C(═O)NR2bR2c, —CH2NR2bR2c, —CH2OR2a, —NR2bR2c, —NHC(═O)R2a, —NHC(═O)NR2bR2c or —NHC(═NH)NR2bR2c;
• R2a is hydrogen, alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl;
• R2b and R2c are the same or different and independently hydrogen, alkyl, substituted alkyl, —SO2R4, —C(═NH)NH2 or —C(═O)R2d where R2d is amino, alkyl, substituted alkyl, aryl or substituted aryl;
• R3 is hydroxy, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, substituted heterocyclealkyl, —C(═O)N(R3a)(R3b), —NHC(═O)N(R3a)(R3b), —NHC(═S)N(R3a)(R3b), —C(═O)OR3c, —C(═O)R3c, —NHC(═O)R3d or —NHSO2R3d;
• R3a and R3b are the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl or substituted arylalkyl,
• or R3a and R3b taken together with the nitrogen atom to which they are attached form a heterocycle or substituted heterocycle;
• Rc is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• R3d is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• and
• R4 is, at each occurrence, the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl or substituted arylalkyl.