Carboxylated polysaccharides and method of preparation and use
AssigneeBoard of Trustees of Michigan State University
InventorsRamani Narayan, Laura Fisher
Life of this patent
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Abstract
Chemically modified dicarboxy polysaccharides are described. The modified polysaccharides are useful as a carrier for cosmetics, pharmaceuticals, veterinary products and the like. The modified polysaccharides can provide a timed release of active ingredients.
Claims13
A process for the preparation of carboxylic acid moieties on a chemically modified polysaccharide (CMP) which comprises:
- (a) selectively oxidizing in an aqueous solution a polysaccharide of linked saccharide rings so that saccharide rings are opened to provide C2 and C3 aldehyde moieties;
- and
- (b) selectively oxidizing all or some of the aldehyde moieties to form the carboxylic acid moieties to provide the carboxylic acid moieties on the CMP and wherein the CMP is water dispersible.
A chemically modified polysaccharide (CMP) comprising linked saccharide rings with ring opened saccharide units at C2 and C3 bond and containing carboxylic acid moieties or water dispersible salt as a random copolymer wherein the CMP is water dispersible to form a clear solution.
A pharmaceutical composition which comprises:
- (a) a medicament;
- and
- (b) a chemically modified polysaccharide (CMP) comprising linked saccharide rings with ring opened saccharide units at C2 or C3 bond and containing carboxylic acid moieties or water dispersible salt as a random copolymer wherein the CMP is water dispersible to form a clear solution as a time release adjuvant for the medicament.
A method for providing a timed release medicament to a tissue of an animal in need thereof which comprises:
- (a) providing a composition which comprises:
- a medicament;
- and a chemically modified polysaccharide (CMP) comprising linked saccharide rings with ring opened saccharide units at C2 or C3 bond and containing carboxylic acid moieties or water dispersible salt as a random copolymer wherein the CMP is water dispersible to form a clear solution as a time release adjuvant for the medicament;
- and
- (b) providing the medicament on the tissue to provide the timed release.
Dependencies are inferred from the claim text.