Crosslinked amine polymers
AssigneeIlypsa, Inc.
InventorsHan Chang, Dominique Charmot, Eric Connor, Florence Roger
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Abstract
The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
Claims20
A method of removing phosphate from an animal comprising administering an effective amount of a crosslinked amine polymer, wherein said polymer comprises an amine of formula V
- wherein each n, independently, is equal to or greater than 3;
- each r, independently, is 0, 1, or 2;
- and each R1, independently, is H or optionally substituted alkyl or aryl or is linked to a neighboring R1 to form an optionally substituted alicyclic, aromatic, or heterocyclic group and said amine is crosslinked with a crosslinking agent.
A polymeric composition comprising a crosslinked amine polymer, wherein said polymer comprises an amine, said amine being at least one of
- and said polymer is crosslinked with a crosslinking agent.
A pharmaceutical composition comprising a crosslinked amine polymer and a pharmaceutically acceptable carrier, wherein said polymer comprises an amine of formula V
- wherein each n, independently, is equal to or greater than 3;
- each r, independently, is 0, 1, or 2;
- and each R1, independently, is H or optionally substituted alkyl or aryl or is linked to a neighboring R1 to form an optionally substituted alicyclic, aromatic, or heterocyclic group and said amine is crosslinked with a crosslinking agent.
A composition comprising core-shell particles wherein said core-shell particles comprise a polymeric core component and a polymeric shell component, said polymeric core component comprising an amine of formula V
- wherein each n, independently, is equal to or greater than 3;
- each r, independently, is 0, 1, or 2;
- and each R1, independently, is H or optionally substituted alkyl or aryl or is linked to a neighboring R1 to form an optionally substituted alicyclic, aromatic, or heterocyclic group and said amine is crosslinked with a crosslinking agent.
Dependencies are inferred from the claim text.