Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur

A compound of the formula

• Type I
• Wherein
• A,C=Rest (linear, branched or cyclic alkyl, alkenyl or alkynyl with or without OH substituents or halides, phenyl, phenylalkyl, phenylalkenyl, phenylalkynyl, phenylcycloalkyl, phenylcycloalkenyl, phenylcycloalkynyl, cycloalkyl-alkyl, cycloalkyl-alkenyl, cycloalkyl-alkynyl, heterocyclo-alkyl, heterocyclo-alkenyl, heterocyclo-alkynyl, acyl, aryl, aryloxy, heteroaryl, heteroaryloxy, aroyl, benzyl, (aryl)alkyloxycarbonyl, linear or branched alkoxyalkyl with or without OH substituents, polyethoxy-alkyl, polyethoxy-alkenyl, polyethoxy-alkynyl, polyethoxy-cycloalkyl, polyethoxy-cycloalkenyl, polyethoxy-cycloalkynyl, polyethoxy-aryl, polyethoxy-alkyl-aryl, polyethoxy-heterocycloalkyl, polyethoxy-heterocycloaryl, primary, secondary, tertiary or quaternary ammonium, amino-alkyl, amino-alkenyl, amino-alkynyl, amino-cycloalkyl, amino-alkyl-cycloalkyl, amino-cycloalkyl-alkyl, amino-phenyl, amino-alkyl-phenyl, amino-phenyl-alkyl, all hydroxylamines, all cyano compounds, all nitriles and isonitriles, all halides thereof, formyl, alkanal, alkenal, alkynal, cycloalkenal, benzyl carbaldehyde, heteroaryl-carbaldehyde, benzyl-alkyl-carbaldehyde, heteroaryl-carbaldehyde, aliphatic heteroalkyl-alkenal (-alkenyl-alkenal, alkynyl-alkenal), alkanone, alkenone, alkynone, cycloalkyl-alkanone, dicycloalkanone, arylalkanone, heteroaryl-alkanone, nitro, alkylsulfoxy, alkylsulfonyl, CONH2, CONHR, CONR2, all imines, all oximes, all hydrazones, CH═NOR, thio, thio-alkyl, thio-alkenyl, thio-alkynyl, thio-cycloalkyl, thio-alkyl-cycloalkyl, thio-cycloalkyl-alkyl, thio-phenyl, thio-alkyl-phenyl, thio-phenyl-alkyl, alkylthio, halide, hydroxy, hydroxy-alkyl, hydroxy-alkenyl, hydroxy-alkynyl, hydroxy-cycloalkyl, hydroxy-alkyl-cycloalkyl, hydroxy-cycloalkyl-alkyl, hydroxy-phenyl, hydroxy-alkyl-phenyl, hydroxy-phenyl-alkyl, alkoxy, alkoxycarbonyl, alkyl-, alkenyl, alkynyl-, aryl-, heteroalkyl-, heteroaryl-carboxylic acids, and all esters as well as carboxylic acid amides thereof, linear or branched alkylsulphonate, alkenylsulphonate, alkynylsulphonate, linear or branched alkylbenzenesulphonate, alkenylbenzenesulphonate, alkynylbenzenesulphonate, aminosulphonyl-alkyl, aminosulphonyl-alkenyl, aminosulphonyl-alkynyl, aminosulphonyl-cycloalkyl, aminosulphonyl-cycloalkenyl, aminosulphonyl-cycloalkynyl, linear or branched alkyl-sulphonamide, alkenyl-sulphonamide, alkynyl-sulphonamide, cycloalkyl-sulphonamide, cycloalkenyl-sulphonamide, cycloalkynyl-sulphonamide, phenyl-sulphonamide, heterocyclo-sulphonic acid, heterocyclo-sulphonamide, heterocyclo-alkyl-sulphonic acid, heterocyclo-alkyl-sulphonic acid, heterocyclo-alkenyl-sulphonic acid, heterocyclo-alkenyl-sulphonamide, heterocyclo-alkynyl-sulphonic acid, heterocyclo-alkynyl-sulphonic acid, aryl-sulphonic acid, aryl-sulphonamide, aryl-alkyl-sulphonic acid, aryl-alkyl-sulphonamide, aryl-alkenyl-sulphonic acid, aryl-alkenyl-sulphonamide, aryl-alkynyl-sulphonic acid, aryl-alkynyl-sulphonamide, alkyl-, alkenyl, alkynyl-, aryl-, heteroalkyl-, heteroaryl-phosphonic acids as well as all esters and amides thereof, alkyl-, alkenyl, alkynyl-, aryl-, heteroalkyl-, heteroaryl-phosphinic acids as well as all esters and amides thereof), comply with donor-acceptor distances of 3.5-4.0 Å and acceptor-donor distances of 2.6-2.9 Å, so that they recognise and bind β-sheet structures of peptides or proteins.

A compound of the formula

• Wherein
• A,C=Rest (linear, branched or cyclic alkyl, alkenyl or alkynyl with or without OH substituents or halides, phenyl, phenylalkyl, phenylalkenyl, phenylalkynyl, phenylcycloalkyl, phenylcycloalkenyl, phenylcycloalkynyl, cycloalkyl-alkyl, cycloalkyl-alkenyl, cycloalkyl-alkynyl, heterocyclo-alkyl, heterocyclo-alkenyl, heterocyclo-alkynyl, acyl, aryl, aryloxy, heteroaryl, heteroaryloxy, aroyl, benzyl, (aryl)alkyloxycarbonyl, linear or branched alkoxyalkyl with or without OH substituents, polyethoxy-alkyl, polyethoxy-alkenyl, polyethoxy-alkynyl, polyethoxy-cycloalkyl, polyethoxy-cycloalkenyl, polyethoxy-cycloalkynyl, polyethoxy-aryl, polyethoxy-alkyl-aryl, polyethoxy-heterocycloalkyl, polyethoxy-heterocycloaryl, primary, secondary, tertiary or quaternary ammonium, amino-alkyl, amino-alkenyl, amino-alkynyl, amino-cycloalkyl, amino-alkyl-cycloalkyl, amino-cycloalkyl-alkyl, amino-phenyl, amino-alkyl-phenyl, amino-phenyl-alkyl, all hydroxylamines thereof, all cyano compounds thereof, all nitriles and isonitriles, all halides, formyl, alkanal, alkenal, alkynal, cycloalkenal, benzyl carbaldehyde, heteroaryl-carbaldehyde, benzyl-alkyl-carbaldehyde, heteroaryl-carbaldehyde, aliphatic heteroalkyl-alkenal (-alkenyl-alkenal, alkynyl-alkenal), alkanone, alkenone, alkynone, cycloalkyl-alkanone, dicycloalkanone, arylalkanone, heteroaryl-alkanone, nitro, alkylsulfoxy, alkylsulfonyl, CONH2, CONHR, CONR2, all imines, all oximes, all hydrazones, CH═NOR, thio, thio-alkyl, thio-alkenyl, thio-alkynyl, thio-cycloalkyl, thio-alkyl-cycloalkyl, thio-cycloalkyl-alkyl, thio-phenyl, thio-alkyl-phenyl, thio-phenyl-alkyl, alkylthio, halide, hydroxy, hydroxy-alkyl, hydroxy-alkenyl, hydroxy-alkynyl, hydroxy-cycloalkyl, hydroxy-alkyl-cycloalkyl, hydroxy-cycloalkyl-alkyl, hydroxy-phenyl, hydroxy-alkyl-phenyl, hydroxy-phenyl-alkyl, alkoxy, alkoxycarbonyl, alkyl-, alkenyl, alkynyl-, aryl-, heteroalkyl-, heteroaryl-carboxylic acids, all esters as well as carboxylic amides thereof, linear or branched alkylsulphonate, alkenylsulphonate, alkynylsulphonate, linear or branched alkylbenzenesulphonate, alkenylbenzenesulphonate, alkynylbenzenesulphonate, aminosulphonyl-alkyl, aminosulphonyl-alkenyl, aminosulphonyl-alkynyl, aminosulphonyl-cycloalkyl, aminosulphonyl-cycloalkenyl, aminosulphonyl-cycloalkynyl, linear or branched alkyl-sulphonamide, alkenyl-sulphonamide, alkynyl-sulphonamide, cycloalkyl-sulphonamide, cycloalkenyl-sulphonamide, cycloalkynyl-sulphonamide, phenyl-sulphonamide, heterocyclo-sulphonic acid, heterocyclo-sulphonamide, heterocyclo-alkyl-sulphonic acid, heterocyclo-alkyl-sulphonic acid, heterocyclo-alkenyl-sulphonic acid, heterocyclo-alkenyl-sulphonamide, heterocyclo-alkynyl-sulphonic acid, heterocyclo-alkynyl-sulphonic acid, aryl-sulphonic acid, aryl-sulphonamide, aryl-alkyl-sulphonamide, aryl-alkyl-sulphonamide, aryl-alkenyl-sulphonic acid, aryl-alkenyl-sulphonamide, aryl-alkynyl-sulphonic acid, aryl-alkynyl-sulphonamide, alkyl-, alkenyl, alkynyl-, aryl-, heteroalkyl-, heteroaryl-phosphonic acids and all esters and amides thereof, alkyl-, alkenyl, alkynyl-, aryl-, heteroalkyl-, heteroaryl-phosphinic acids and all esters as well as amides thereof) comply with donor-acceptor distances of 3.5-4.0 Å and acceptor-donor distances of 2.6-2.9 Å so that they recognise and bind β-sheet structures of peptides or proteins.