Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
AssigneesDuke University, The Johns Hopkins University
InventorsJonathan Stamler, Eric Toone, Joshua Hare
Life of this patent
Estimating the term…
Abstract
A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, e.g., 1,5-bis(3-nitrooxypropyyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle. Where the disorder is heart failure, administration of the enzyme inhibitor mediates amelioration of acute coronary symptoms and/or myocardial infarction.
Claims32
An inhibitor of a reactive oxygen generating enzyme which includes a group providing NO donor bioactivity which is not a C-nitroso compound or an inhibitor of a cyclooxygenase, said inhibitor being selected from the group consisting of allopurinol, oxypurinol, pterin-6-aldehyde, 6-formylpterin, nordihydroguaiaretic acid, 17-octadecynoic acid, miconazole, ketoconazole, diphenyl iodonium chloride, diphenyl iodonium sulfate, apocyin, bentomyl, disulfiram, phenethyl isothiocyanate, cyanamide, cimetidine, menadione, isovanillin, CV6504, ABT761, zileuton, linoleyl hydroxamic acid, panaxynol, mersalyl, diphenylene iodonium, pegalated zinc protoporphyrin, Co (III) protoporphyrin, Sn protoporphyrin, tin mesoporphyrin, rotenone, MPTP, antinycin, 11-Qol MET and mixtures thereof, provided with a nitrate group or a nitroso group thereon.
Dependencies are inferred from the claim text.