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US 2005/0239802 A1Published application
(2-((2-alkoxy)-phenyl)-cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
AssigneeGlaxo Group Limited
InventorsGerard Martin Giblin, Adrian Hall, David Hurst, Ian Kilford, Xiao Lewell, Alan Taylor, Riccardo Novelli
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
Claims21
A compound of formula (I):
- wherein:
- A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclyl ring, or an optionally substituted bicyclic heterocyclyl group;
- R1 is CO2R4, CONR5R6, CH2CO2R4, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted SO2alkyl, SO2NR5R6, NR5CONR5R6, CONR5R6, 2H-tetrazol-5-yl-methyl or optionally substituted heterocyclyl;
- each R2 is independently halo, optionally substituted alkyl, CN, SO2R5, SR5, NO2, optionally substituted aryl, CONR5R6 or optionally substituted heteroaryl;
- Rx is optionally substituted alkyl wherein 1 or 2 of the non-terminal carbon atoms may optionally be replaced by a group independently selected from NR4, O or SOn, wherein n is 0, 1 or 2:
- or Rx may be optionally substituted CQ2-heterocyclyl or optionally substituted CQ2-phenyl wherein Q is independently selected from hydrogen and CH3;
- R4 is hydrogen or an optionally substituted alkyl;
- R5 is hydrogen or an optionally substituted alkyl;
- R6 is hydrogen or an optionally substituted alkyl, optionally substituted SO2aryl, optionally substituted SO2heterocyclyl group, CN, optionally substituted CH2aryl or COR7;
- R7 is hydrogen, optionally substituted heteroaryl or optionally substituted aryl;
- R8 and R9 independently is hydrogen or alkyl;
- and
- n is an integer from 0 to 2;
- wherein when A is a 6-membered ring the R1 and cyclopentene group are attached to carbon atoms 1,2-, 1,3- or 1,4-relative to each other, and when A is a five-membered ring or bicyclic heterocyclyl group the R1 and cyclopentene group are attached to substitutable carbon atoms 1,2- or 1,3-relative to each other;
- or a pharmaceutically acceptable derivative thereof.
12 more elements
A compound selected from:
- {2-[5-chloro-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[2-(benzyloxy)-phenyl]-cyclopent-1-enyl]-benzoic acid;
- 3-{2-[5-bromo-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-bromo-2-(4-Chlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-bromo-2-(4-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-bromo-2-(3,4-dichlorobenzyloxy)-penyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-bromo-2-(4-chloro-2-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-bromo-2-(4-methoxybenzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 5-{2-[5-chloro-2-(4-chlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-chloro-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-chloro-2-(3,4-dichlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-chloro-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-chloro-2-(4-chloro-2-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-chloro-2-(4-methoxybenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(4-chlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(4-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(4-chloro-2-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(4-methoxybenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-bromo-2-(cyclohexylmethoxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-trifluoromethyl-2-(4-chlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-trifluoromethyl-2-(4-chloro-2-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid;
- 5-{2-[5-trifluoromethyl-2-(cyclohexylmethoxy)-phenyl]-cyclopent-1-enyl]-nicotinic acid;
- 6-{2-[5-chloro-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(4-chloro-2-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(4-chlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-pyridine 2-carboxylic acid;
- 6-{2-[5-chloro-2-(4-fluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-pyridine 2-carboxylic acid;
- 3-{2-[5-methylsulfonyl-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-methylsulfonyl-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-methylsulfonyl-2-(4-fluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-methanesulfonyl-2-(4-fluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-methylsulfonyl-2-(2,4-difluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-methanesulfonyl-2-(2,4-difluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[2-(2,4-difluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[2-(4-chloro-2-fluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[2-(4-methoxy-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-cyano-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-cyano-2-(2,4-difluoro-benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic acid;
- 2-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyrimidine-4-carboxylic acid;
- 6-{2-[5-methyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-methyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 2-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-4-carboxylic acid;
- 2-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-4-carboxylic acid;
- 4-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 4-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-aminopyrazine-2-carboxylic acid;
- 2-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrimidine-4-carboxylic acid;
- 2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrimidine-4-carboxylic acid;
- 6-{2-[5-methyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 3-{2[5-methyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid;
- 6-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 3-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-6-acetamidobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-acetamidobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-acetamidobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-propionamidobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-propionamidobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-propionamidobenzoic acid;
- 3-{2-[5-bromo-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-propionamidobenzoic acid;
- 3-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-propionamidobenzoic acid;
- 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-propionamidobenzoic acid;
- 5-{2-[trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}nicotinic acid N-oxide;
- 5-{2-[5-fluoro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(propionamido)benzoic acid;
- 5-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(propionamido)benzoic acid;
- 5-{2-[5-methyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(propionamido)benzoic acid;
- 5-[2-(2-benzyloxy-5-chlorophenyl)cyclopent-1-enyl]-2-methylbenzoic acid;
- 5-[2-(2-Benzyloxy-5-chlorophenyl)-cyclopent-1-enyl]-2-propionylaminobenzoic acid;
- 2-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}isonicotinic acid;
- 2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}isonicotinic acid;
- 2-{2-[5-chloro-2-benzyloxyphenyl]cyclopent-1-enyl}isonicotinic acid;
- 2-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}isonicotinic acid;
- 5-[2-(2-benzyloxy-5-chlorophenyl)cyclopent-1-enyl]-3-propionylaminobenzoic acid;
- 5-[2-(2-benzyloxy-5-chlorophenyl)cyclopent-1-enyl]-3-isobutyrylaminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxo-pyrrolidin-1-yl)benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxo-pyrrolidin-1-yl)benzoic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxo-pyrrolidin-1-yl)benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxo-piperidin-1-yl)benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxo-piperidin-1-yl)benzoic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxo-piperidin-1-yl)benzoic acid;
- 6-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-aminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-aminobenzoic acid;
- 5-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-aminobenzoic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-aminobenzoic acid;
- 5-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-aminobenzoic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-methanesulphonylaminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-methanesulphonylaminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-methanesulphonylaminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-methanesulphonylamino benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-acetamidobenzoic acid
- 5-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-acetamidobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-acetamidobenzoic acid;
- 5-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-acetamidobenzoic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-acetamidobenzoic acid;
- 5-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopenten-1-enyl}-3-acetamidobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-(morpholin-4-yl)benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(morpholin-4-yl)benzoic acid;
- 5-{2-[5-chloro-2-(−4-fluorobenzyloxy)phenyl]cyclopenten-1-enyl}-3-(morpholin-4-yl)benzoic acid;
- 5-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-methylaminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-methylaminobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-methylaminobenzoic acid;
- 2{2-[5-trifluoromethyl-2-(2,4-diflurobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-4-carboxylic acid;
- 2{2-[5-bromo-2-(2,4-diflurobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-4-carboxylic acid;
- 2{2-[5-bromo-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-4-carboxylic acid;
- 2-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrazine-5-amino-6-carboxylic acid;
- 2-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-aminopyrazine-6-carboxylic acid;
- 3-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic acid;
- 3-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic acid;
- 6-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 5-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(morpholin-4-yl)benzoic acid;
- 5-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopenten-1-enyl}-3-morpholin-4-ylbenzoic acid;
- 5-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopenten-1-enyl}-3-(morpholin-4-yl)benzoic acid;
- 5-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-methanesulphonylaminobenzoic acid;
- 5-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-methanesulphonylamino benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-diethylaminobenzoic acid;
- 6-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 6-{2-[5-methyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid;
- 6-{2-[5-fluoro-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-fluoro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-fluoro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridazine-4-carboxylic acid;
- 6-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridazine-4-carboxylic acid;
- 6-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridazine-4-carboxylic acid;
- 5-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-2-methylbenzoic acid;
- 5-[2-(2-(4-fluorobenzyloxy)-5-chlorophenyl)cyclopent-1-enyl]-2-methylbenzoic acid;
- 5-[2-(2-(4-fluorobenzyloxy)-5-chlorophenyl)cyclopent-1-enyl]-2-fluorobenzoic acid;
- 5-[2-(2-benzyloxy)-5-chlorophenyl)cyclopent-1-enyl]-2-fluorobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}nicotinic acid;
- 4-{2-[2-(benzyloxy)phenyl]cyclopent-1-enyl}-benzoic acid;
- 4-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-benzoic acid;
- 3-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic acid;
- 3-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic acid;
- 3-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic acid;
- 3-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic acid;
- 3-{2-[5-chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic acid;
- 2-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]-cyclopent-1-enyl}-isonicotinic acid;
- 2-{2-[2-(4-fluorobenzyloxy)phenyl]-cyclopent-1-enyl}-isonicotinic acid;
- 6-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(4-bromobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(2-chloro-4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(2,4,6-trifluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(2,6-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(2-fluoro-4-trifluoromethylbenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(3,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 6-{2-[5-chloro-2-(2,3-difluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid sodium salt;
- 6-{2-[5-chloro-2-(4-methylbenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid sodium salt;
- 6-{2-[5-chloro-2-(4-trifluoromethylbenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid;
- 3-{2[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-aminobenzoic acid;
- 2-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}pyrimidine-4-carboxylic acid;
- 5-{2-[5-methyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-2-acetamidobenzoic acid;
- 3-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-6-fluorobenzoic acid;
- 5-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-2-methylbenzoic acid;
- 5-{2-[5-chloro-2-(2,4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxopyrrolidin-1-yl)benzoic acid;
- 5-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxopyrrolidin-1-yl)benzoic acid;
- 5-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxopyrrolidin-1-yl)benzoic acid;
- 5-{2-[5-chloro-2-(2,4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxopiperidin-1-yl)benzoic acid;
- 5-{2-[5-chloro-2-(benzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxopiperidin-1-yl)benzoic acid;
- and
- 5-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-3-(2-oxopiperidin-1-yl)benzoic acid
- and pharmaceutically acceptable derivatives thereof.
173 more elements
8-9. (canceled)
13-16. (canceled)
6-{2-[5-Chloro-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-pyridine-2-carboxylic acid or a pharmaceutically acceptable derivative thereof.
6-{2-[5-Chloro-2-(2,4-difluorobenzyloxy)-phenyl]-cyclopent-1-enyl}-pyridine-2-carboxylic acid.
Dependencies are inferred from the claim text.