Protein kinase inhibitors

A compound having the following structure:

• or a steroisomer, prodrug or pharmaceutically acceptable salt thereof, wherein:
• X is NH, S or O;
• Z is CH or N;
• R1 and R2 are the same or different and are independently hydrogen, hydroxyl, halo, —CN, —NO2, —NH2, —R, —OR, —SCH3, —CF3, —C(═O)OR or —OC(═O)R, where R is alkyl or substituted alkyl;
• R3 is hydrogen, —NH2, alkyl, —CN, or —NO2, or R3 is -L3-Cycl3 wherein L3 is a direct bond, S or NH, and Cycl3 is a carbocycle, substituted carbocycle, heterocycle or substituted heterocycle;
• L2 is selected from —NHCH2—, —NH—, —C(═S)NH—, —NHC(═S)—, —C(═S)NHCH2—, —NHC(═S)NH—, —NHC(═O)—, —NHC(═O)NH—;
• —S(═O)2—;
• and
• Cycl2 is:
• where w is