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US 2005/0239773 A1Published application
Diazabicyclonane and-decane derivatives and their use as opioid receptor ligands
AssigneeNeuroSearch A/S
InventorsDan Peters, Gunnar Olsen, Elsebet Nielsen
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Abstract
This invention relates to novel diazabicyclononane and -decane derivatives useful as opioid receptor ligands. More specifically, the invention provides compounds useful as μ opioid receptor ligands.
Claims11
A compound of general formula (I),
- any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof,
- wherein
- Q is —CH2—CH2— or —CH2—CH2—CH2—;
- one of R1 and R2 is —CH2—CH2—CH2—R3, —CH2—CH═CH—R3, or —CH2—C≡C—R3;
- wherein R3 is aryl or heteroaryl;
- which aryl and heteroaryl is optionally substituted with one or more substituents selected from the group consisting of:
- halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl;
- and
- the other of R1 and R2 is —CO—R4;
- wherein R4 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, or arylalkyl.
7 more elements
(canceled)
Dependencies are inferred from the claim text.