Estriol therapy for multiple sclerosis and other autoimmune diseases
AssigneeThe Regents of the University of California
InventorRhonda Voskuhl
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Abstract
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including: multiple sclerosis (MS), rheumatoid arthritis (RA), autoimmune thyroiditis and uveitis. Most preferably the invention is used to treat a patient with a therapeutically effective amount of estriol of 8 milligrams once daily via oral administration to treat the symptoms or prevent the onset of multiple sclerosis.
Claims20
A method of treating a human patient exhibiting clinical symptoms of multiple sclerosis comprising administering at least estirol a therapeutically effective dosage in an effective dosage form at a selected interval to ameliorate the symptoms of the multiple sclerosis.
2-4. (canceled)
9-10. (canceled)
13-19. (canceled)
A method of treating a patient exhibiting clinic symptoms of multiple sclerosis comprising administering 8 milligrams of estriol daily to ameliorate the disease.
22-25. (canceled)
A method of treating a patient exhibiting clinical symptoms of multiple sclerosis to ameliorate the disease comprising administering estriol at a dose of about 4 to about 16 milligrams of estriol daily;
- and glatiramer acetate copolymer-1 at a dose of about 0 mg to about 20 mg daily.
(canceled)
A method of treating a patient exhibiting clinically isolated syndrome as a precursor to multiple sclerosis, comprising administering estriol at a therapeutically effective dosage in an effective dosage form at a selected interval to delay the onset of additional symptoms multiple sclerosis.
32-39. (canceled)
Dependencies are inferred from the claim text.