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US 2005/0239761 A1Published application
Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
AssigneeG.D. Searle & Co.
InventorsJohn Ng, Ping Wang, Julio Baez, Chin Liu, Dennis Anderson, Jon Lawson, Bernhard Erb, Joseph Wieczorek, Gennaro Mucciariello, Fortunato Vanzanella, Sastry Kunda, Leo Letendre, Mark Pozzo, Yuen-Lung Sing, Edward Yonan
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Abstract
Novel 9α-hydroxy steroid compounds, including compounds of Formula IX wherein -A-A-, —B—B—, R1, R3, R8 and R9 are as defined in the specification.
Claims20
A compound of Formula XIV:
- wherein:
- -A-A- represents the group —CHR4—CHR5— or —CR4═CR5—;
- R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, and aryloxy;
- and
- —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group of Formula III:
- where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, and aryloxy.
3 more elements
A compound corresponding to Formula XXI:
- wherein:
- -A-A- represents the group —CHR4—CHR5— or —CR4═CR5—;
- R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, and aryloxy;
- —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group of Formula III:
- where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, and aryloxy;
- and
- R8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, acyloxyalkyl, cyano, and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
4 more elements
A compound corresponding to Formula XXIII:
- wherein:
- -A-A- represents the group —CHR4—CHR5— or —CR4═CR5—;
- R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, and aryloxy;
- —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group of Formula III:
- where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, and aryloxy;
- and
- R8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, acyloxyalkyl, cyano, and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
4 more elements
A compound corresponding to Formula XXVI:
- wherein:
- -A-A- represents the group —CHR4—CHR5— or —CR4═CR5—;
- R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, and aryloxy;
- —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group of Formula III:
- where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, and aryloxy;
- and
- Rx is selected from the group consisting of hydrogen and hydroxy protecting groups.
4 more elements
Dependencies are inferred from the claim text.