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US 2005/0239754 A1Published application
S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine salicylate monohydrate crystalline salt
OwnerLyle Brostrominventor
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Abstract
A crystalline salicylate monohydrate salt of S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine is disclosed. A method to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine is further disclosed. In addition, methods of use for crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine are disclosed
Claims9
A crystalline form of S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine salicylate monohydrate characterized by at least one of:
- x-ray powder pattern substantially as shown in FIG. 6;
- Raman spectrum substantially as shown in FIG. 12;
- and elemental analysis substantially as in Table 5.
A method of making S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine salicylate monohydrate comprising:
- obtaining S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine zwitterion;
- adding the S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine zwitterion to an appropriate solvent;
- adding a salicylic acid to the S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine and solvent;
- and
- adding an antisolvent to precipitate S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine salicylate monohydrate crystals.
2 more elements
Dependencies are inferred from the claim text.