Combined use of derivatives of GLP-1 analogs and PPAR ligands
OwnerLiselotte Knudsen, Karsten Wassermann +2inventors
InventorsLiselotte Knudsen, Karsten Wassermann, Jeppe Sturis, Christian Brand
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Abstract
The present invention provides methods and compositions for treatment and/or prevention of type 1 and type 2 diabetes, dyslipdemia, impaired glucose tolerance, insulin resistance, obesity, and beta-cell apoptosis, as well as methods for increasing the size and number of beta-cells in a subject and/or stimulating beta-cell proliferation, which comprise administering both a stable GLP-1 analogue and a non-thiazolidinedione PPAR ligand.
Claims6
A method for increasing the number of beta-cells in a subject, increasing the size of beta-cells in a subject or stimulating beta-cell proliferation, said method comprising administering to a patient in need thereof (i) a first amount of a stable derivative of a GLP-1 analog and (ii) a second amount of a non-thiazolidinedione PPAR ligand, wherein said first and second amounts in combination are effective to increase the number and/or size of beta-cells or to stimulate beta-cell proliferation.
A method for increasing the number of beta-cells in a subject, increasing the size of beta-cells in a subject or stimulating beta-cell proliferation, said method comprising administering to a patient in need thereof (i) a first amount of a stable derivative of a GLP-1 analog and (ii) a second amount of an insulin sensitizer selected from the group consisting of pioglitazone and rosiglitazone, wherein said first and second amounts in combination are effective to increase the number and/or size of beta-cells in a subject and/or to stimulate beta-cell proliferation.
Dependencies are inferred from the claim text.