Compositions and methods for topical diagnostic and therapeutic transport
AssigneeEssentia Biosystems, Inc.
InventorsMichael Dake, Jacob Waugh
Life of this patent
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Abstract
Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternately, the compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.
Claims191
A composition comprising a biologically active protein and a carrier which comprises polymeric backbone having attached positively charged branching groups and which is present in an effective amount for transdermal delivery, wherein the association between the carrier and the biologically active protein is non-covalent.
A composition comprising a non-protein non-nucleotide biologically active agent and a carrier which comprises a polymeric backbone having attached positively charged branching groups and which is present in an effective amount for transdermal delivery, wherein the association between the carrier and the biologically active agent is non-covalent.
A kit for administration of a biologically active protein to a subject comprising a device for delivering the biologically active protein to the skin or epithelium and a composition comprising a polymeric carrier having attached positively charged branching groups selected from -(gly)n1-(arg)n2, HIV-TAT and fragments thereof, and Antennapedia PTD and fragments thereof, in which the subscript n1 is an integer of from 0 to about 20, and the subscript n2 is independently an odd integer of from about 5 to about 25, wherein the association between the carrier and the biologically active protein is non-covalent.
A method of administering a biologically active protein to a subject comprising topically applying to the skin or epithelium of the subject the protein in conjunction with an effective amount of a carrier comprising a polymeric backbone having attached positively charged branching groups, wherein the association between the carrier and the biologically active protein is non-covalent.
A method of administering a non-protein non-nucleotide biologically active agent to a subject comprising topically applying to the skin or epithelium of the subject the biologically active agent in conjunction with an effective amount of a carrier comprising a polymeric backbone having attached positively charged branching groups, wherein the association between the carrier and the biologically active agent is non-covalent.
A composition comprising an antigen suitable for immunization and a carrier which comprises a polymeric backbone having attached positively charged branching groups and which is present in an effective amount for transdermal delivery, wherein the association between the carrier and the antigen is non-covalent.
A kit for administration of an antigen suitable for immunization to a subject comprising a device for delivering the antigen suitable for immunization to the skin or epithelium and a composition comprising a carrier consisting of a polymeric backbone having attached positively charged branching groups selected from -gly)n1-(arg)n2, HIV-TAT and fragments thereof, and Antennapedia PTD, in which the subscript n1 is an integer of from 0 to about 20, and the subscript n2 is independently an odd integer of from about 5 to about 25, wherein the association between the carrier and the antigen is non-covalent.
A method of administering an antigen suitable for immunization to a subject comprising topically applying to the skin or epithelium of the subject the antigen suitable for immunization in conjunction with an effective amount of a carrier comprising a polymeric backbone having attached positively charged branching groups, wherein the association between the carrier and the antigen is non-covalent.
A composition comprising an imaging moiety and a targeting agent and a carrier which comprises a polymeric backbone having attached positively charged branching groups and which is present in an effective amount for transdermal delivery, wherein the association between the carrier and the imaging moiety or targeting agent is non-covalent.
A method of administering an imaging moiety and a targeting agent to a subject comprising topically applying to the skin or epithelium of the subject the imaging moiety and targeting agent in conjunction with an effective amount of a carrier comprising a polymeric backbone having attached positively charged branching groups, wherein the association between the carrier and the biologically active protein is non-covalent.
Dependencies are inferred from the claim text.