Gmg-3 gmg-4 and gmg-6 polynucleotides and polypeptides and uses thereof

A method of treating or preventing a metabolic-related disease or disorder comprising the step of administering to an individual a composition comprising a polypeptide or biologically active fragment thereof, wherein said polypeptide or fragment thereof comprises all or part of a C-terminal globular C1q homology domain and wherein said polypeptide is selected from the group consisting of:

• (a) SEQ ID NO:
• 2;
• and
• (b) SEQ ID NO:
• 4.

An isolated polypeptide fragment selected from the group consisting of:

• (a) amino acids 20-333 of SEQ ID NO:
• 2;
• (b) amino acids 188-333 of SEQ ID NO:
• 2;
• (c) amino acids 191-333 of SEQ ID NO:
• 2;
• (d) amino acids 193-333 of SEQ ID NO:
• 2;
• (e) amino acids 252-317 of SEQ ID NO:
• 2;
• (f) amino acids 20-333 of SEQ ID NO:
• 4;
• (g) amino acids 188-333 of SEQ ID NO:
• 4;
• (h) amino acids 191-333 of SEQ ID NO:
• 4;
• (i) amino acids 193-333 of SEQ ID NO:
• 4;
• (j) amino acids 252-317 of SEQ ID NO:4;
• (k) amino acids 20-330 of SEQ ID NO:
• 8;
• (l) amino acids 185-330 of SEQ ID NO:
• 8;
• (m) amino acids 188-330 of SEQ ID NO:
• 8;
• (n) amino acids 190-330 of SEQ ID NO:
• 8;
• (o) amino acids 249-314 of SEQ ID NO:
• 8;
• (p) amino acids 20-323 of SEQ ID NO:
• 10;
• (q) amino acids 178-323 of SEQ ID NO:
• 10;
• (r) amino acids 181-323 of SEQ ID NO:
• 10;
• (s) amino acids 183-323 of SEQ ID NO:
• 10;
• and
• (t) amino acids 242-307 of SEQ ID NO:
• 10.