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US 2005/0239692 A1Published application
Aqueous preparation containing oligopeptides and etherified cyclodextrin
AssigneeMerck Patent GmbH
InventorsHiltrud Lindenblatt, Hans-Peter Zobel
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Abstract
The present invention relates to an aqueous pharmaceutical preparation of oligopeptides comprising an oligopeptide of the formula I, cyclo-(n-Arg-nGly-nAsp-nD-nE), and a partially etherified β-cyclodextrin having a water solubility of greater than 1.8 mg/ml of water, and to the preparation of the aqueous pharmaceutical preparation.
Claims13
Aqueous pharmaceutical preparation of oligopeptides, comprising an oligopeptide of the formula I
- cyclo-(n-Arg-nGly-nAsp-nD-nE) (I)
- in which
- D and E each, independently of one another, denote Gly, Ala, β-Ala, Asn, Asp, Asp(OR), Arg, Cha, Cys, Gln, Glu, His, Ile, Leu, Lys, Lys(Ac), Lys(AcNH2), Lys(AcSH), Met, Nal, Nle, Orn, Phe, 4-Hal-Phe, homoPhe, Phg, Pro, Pya, Ser, Thr, Tia, Tic, Trp, Tyr or Val, where the said amino acid radicals may also be derivatised,
- R denotes alkyl having 1-18 C atoms,
- Hal denotes F, Cl, Br, I,
- Ac denotes alkanoyl having 1-10 C atoms, aroyl having 7-11 carbon atoms or aralkanoyl having 8-12 C atoms,
- n denotes a hydrogen atom or an alkyl radical R, benzyl or an aralkyl radical having 7-18 C atoms on the alpha-amino function of the corresponding amino acid radical,
- with the proviso that at least one amino acid radical has a substituent n, where n denotes R,
- and where, if they are radicals of optically active amino acids and amino acid derivatives, both the D and L forms are included, and physiologically acceptable salts thereof,
- and an etherified β-cyclodextrin having a water solubility of greater than 1.8 mg/ml of water
7 more elements
Dependencies are inferred from the claim text.