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AssigneeMonash University
InventorsRichard Mollard, Alan Trounson, Mark Denham
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The present invention relates to methods of inducing differentiation of stem cells into a specific cell lineage, preferably lung cells. In particular, the invention relates to in vitro methods of inducing differentiation of stem cells into a specific cell lineage. The invention also relates to methods of producing and recovering differentiated stem cells of a specific cell lineage. The invention also includes differentiated stem cells and cell lineages produced by the methods of the present invention. In one aspect of the present invention there is provided a method of inducing differentiation of a stem cell into a specific cell lineage, preferably lung cells, the method including: culturing a stem cell in vitro in the presence of a tissue sample and/or extracellular medium of a tissue sample, under conditions that induce differentiation of the stem cell into a specific cell lineage, wherein the differentiated stem cell is the same cell type as the tissue sample.
1-35. (canceled)
A method of inducing differentiation of a stem cell into a specific cell lineage, comprising:
A method of treating a tissue specific disorder, comprising:
A method of treating a tissue specific disorder, comprising:
A differentiated stem cell of a specific stem cell lineage that is prepared by a method which comprises culturing a stem cell in vitro under conditions that induce differentiation of the stem cell into a specific cell lineage, said step of culturing taking place in the presence of at least one of (i) a tissue sample from a tissue, and (ii) extracellular medium from a tissue sample from a tissue, wherein said tissue sample is selected during organogenesis of the tissue.
An intermediate differentiated stem cell of a specific stem cell lineage prepared by a method which comprises culturing a stem cell in vitro under conditions that induce differentiation of the stem cell into a specific cell lineage to produce said intermediate differentiated stem cell, said step of culturing taking place in the presence of at least one of (i) a tissue sample from a tissue, and (ii) extracellular medium from a tissue sample from a tissue, wherein said tissue sample is selected during organogenesis of the tissue, and wherein said intermediate differentiated stem cell is partially differentiated from an embryonic inner cell mass stage to a terminally differentiated stage.
Dependencies are inferred from the claim text.