US 2005/0239178 A1Published application

Labeling of rapamycin using rapamycin-specific methylases

AssigneeWyeth

InventorsMark Ruppen, Pamela Charbonneau

Life of this patent

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Abstract

A method for rapamycin-specific labeling using rapI, rapM and/or rapQ enzymes is described. Also are methods for generating crude enzyme extracts useful in the method of the invention. Uses of the specifically labeled rapamycin as diagnostic tools are provided.

Claims14

Dependent claims

A method for specifically labeling a rapamycin comprising the step of:

reacting a desmethylrapamycin with a rapamycin-specific methylase in the presence of a methylating reagent.

Dependencies are inferred from the claim text.

Facts

Application: 11/113,686Filed 25 Apr 2005
Priority: 27 Apr 2004
Published: 27 Oct 2005
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

C12P 17/188
Containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin: heterocyclic…
A61K 31/4745
Ortho- or peri-condensed with heterocyclic ring systems: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
C07D 498/18
In which the condensed system contains three hetero rings: bridged systems
C12P
Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition

Family

Application60/565,714Us provisional application · filed 27 Apr 2004
US 2005/0239178 A1This patent

From the US filing history. Foreign family members aren’t listed.

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