Alpha-MSH related compounds and methods of use
AssigneeMGI PHARMA Biologics, Inc.
InventorsMary Hedley, Robert Urban, Nazneen Aziz, Hongmin Chen, Bijan Etemad-Moghadam, Peng Yin
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Abstract
The invention provides polypeptides containing α-MSH that can be used to treat diseases characterized by inflammation and/or autoimmunity. Also included in the invention are α-MSH analogs and nucleic acids encoding polypeptides containing α-MSH and α-MSH analogs optionally linked to heterologous sequences. Also included in the invention are methods of delivering α-MSH containing peptides, α-MSH analogs, an DNA encoding α-MSH and α-MSH analogs.
Claims38
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising an α-MSH concatamer.
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising α-MSH and a membrane sequence.
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising α-MSH and a signal sequence.
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising α-MSH and a glycosylphosphatidylinositol (GPI) attachment signal peptide.
A composition comprising a fusion polypeptide comprising an α-MSH concatamer.
A composition comprising a fusion polypeptide comprising α-MSH and a membrane sequence.
A composition comprising a fusion polypeptide comprising α-MSH and a signal sequence.
A composition comprising a fusion polypeptide comprising α-MSH and a GPI attachment signal peptide.
A method of generating regulatory T cells, the method comprising:
- providing a population of T cells in vitro;
- and
- mixing the population of T cells with an α-MSH analog and a therapeutic compound;
- wherein the mixing results in the generation of regulatory T cells in vitro.
A method of generating regulatory T cells, the method comprising administering to an individual an α-MSH analog and a therapeutic compound, wherein the administration results in the generation of regulatory T cells in the individual.
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising an α-MSH analog concatamer.
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising an α-MSH analog and a membrane sequence.
A nfucleic acid comprising a sequence encoding a fusion polypeptide comprising an α-MSH analog and a signal sequence.
A nucleic acid comprising a sequence encoding a fusion polypeptide comprising an α-MSH analog and a GPI attachment signal peptide.
A method of treatment comprising delivering a therapeutic compound and an α-MSH-containing polypeptide to an individual suffering from, or at risk of, a disorder of the immune system.
A method of treatment comprising delivering a therapeutic compound and a nucleic acid encoding an α-MSH-containing polypeptide to an individual suffering from, or at risk of, a disorder of the immune system.
Dependencies are inferred from the claim text.