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US 2005/0239162 A1Published application
Process for folding chemically synthesized polypeptides
AssigneeRMF Dictagene S.A.
InventorsAntonio Verdini, Giampetro Corradin, Mario Roggero
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Abstract
A method is provided for folding chemically synthesized polypeptides having two or more derivatized cysteine residues by contacting with a reducing agent in a folding buffer having a predetermined pH and temperature.
Claims27
A process for folding chemically synthesized polypeptides, comprising treating a polypeptide and/or protein that comprises two or more derivatized cysteine residues with a reducing agent in a folding buffer having a predetermined pH and temperature.
A process for the preparation of biologically active proteins, comprising
- (a) chemically synthesizing a polypeptide that comprises two or more derivatized cysteine residues;
- (b) treating said polypeptide with a reducing agent in a folding buffer having a predetermined pH and temperature;
- and
- (c) purifying the obtained folded polypeptides and/or proteins.
1 more element
Dependencies are inferred from the claim text.