Genetic strain optimization for improving the production of riboflavin
OwnerHenning Althofer, Jose Revuelta Dovalinventors
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Abstract
Process for the microbial production of riboflavin by growing a microorganism of the genus Ashbya which is capable of riboflavin production and which shows higher activities than the wild type ATCC 10895 in at least two of the gene products selected from the group consisting of rib1, rib2, rib4 and rib7, and subsequently isolating the produced riboflavin from the culture medium.
Claims25
A process for microbial production of riboflavin by comprising:
- growing in a culture medium a microorganism of the genus Ashbya which is capable of producing riboflavin that shows a higher riboflavin activity for at least two riboflavin biosynthesis gene products than a microorganism of ATCC 10895 in wherein the at least two riboflavin biosynthesis gene products are selected from the group consisting of rib1, rib2, rib4 and rib7;
- and
- isolating the riboflavin from the culture medium.
A microorganism of the genus Ashbya that is capable of producing at least 110% of the riboflavin of another microorganism of ATCC 10895.
A method for microbial production of riboflavin comprising growing a microorganism of the genus Ashbya that is capable of producing riboflavin wherein the riboflavin produced therefrom has an activity of at least 110% of the riboflavin activity produced by another microorganism of ATCC 10895 as measured for at least two riboflavin biosynthesis gene products.
Dependencies are inferred from the claim text.