A method of calibrating an analyte-measurement device, and associated methods, devices and systems

A method of calibration, comprising:

• inserting a sensor at a measurement site within the body, the sensor sufficient for providing at least one analyte signal indicative of analyte concentration in a bodily fluid at the measurement site;
• obtaining at least two analyte signals via the sensor;
• determining a calibration concentration of the analyte in blood from an off-finger calibration site within the body;
• and
• adjusting the at least two analyte signals based on the calibration concentration.

A method for use in calibrating a signal from a subcutaneous sensor, comprising:

• obtaining one analyte signal from the subcutaneous sensor placed in contact with a subcutaneous fluid of a body;
• obtaining a calibration measurement from a calibration sensor placed in contact with capillary blood from an off-finger calibration site within the body;
• associating a sensitivity with said one analyte signal, said sensitivity being within a predetermined range;
• and
• converting an analyte signal from the subcutaneous sensor into an analyte concentration based on the sensitivity.

A method for use in calibrating a signal from a subcutaneous sensor, comprising:

• obtaining one analyte signal from the subcutaneous sensor placed in contact with a subcutaneous fluid of a body at one time;
• obtaining another analyte signal from the subcutaneous sensor placed in contact with the subcutaneous fluid of the body at another time;
• determining a rate of change in analyte concentration over a period from said one time to said another time;
• and
• evaluating whether the rate of change falls within a predetermined range such that at least one of said one analyte signal and said another analyte signal is suitable for being converted into an analyte concentration.

A method for use in connection with a subcutaneous sensor, comprising:

• obtaining an analyte signal from the subcutaneous sensor placed in contact with a subcutaneous fluid of a body;
• obtaining a calibration measurement from a calibration sensor placed in contact with capillary blood of the body;
• said obtaining the analyte signal and said obtaining a calibration measurement occurring within a period of about 10 minutes of each other;
• evaluating at least one of the analyte signal and the calibration measurement for suitability for use in converting an analyte signal from the subcutaneous sensor into an analyte concentration.

A system for calibrating a signal from a sensor, comprising:

• a measurement sensor sufficient for providing an analyte signal indicative of a concentration of an analyte in a bodily fluid at a measurement site within a body;
• a calibration sensor sufficient for determining a calibration concentration of the analyte in blood from a calibration site within the body;
• and
• a calibration device in operative communication with the measurement sensor and the calibration sensor for receipt of data therefrom, the device comprising:
• a receiving element for receiving at least one analyte signal from the measurement sensor;
• a receiving element for receiving at least one calibration value for the calibration concentration from the calibration sensor;
• and
• a calibration element for calibrating the at least one analyte signal based on the at least one calibration value, said calibration element being other than manual.