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US 2005/0239149 A1Published application
Chemiluminescence enhancer
AssigneeFujirebio Inc.
InventorsKazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
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AssigneeFujirebio Inc.
InventorsKazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
Estimating the term…
The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.
A chemiluminescence enhancer used for signal detection in solid phase immunoassay using antigen or/and antibody immobilized on a fine solid carrier dispersible in liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a phosphonium salt for enhancing emission of light caused by enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein aggregation inhibition treatment of the fine solid carriers is given by treating with an oxidizing agent or a reducing agent.
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