Interactive system for presenting and eliminating substances

A method of binding, cleaving, or otherwise modifying a target substance in a liquid comprising contacting a liquid with an interactive system comprising:

• (a) a surface of a plastic material selected from the group consisting of a poly(meth)acrylate polymer, a polyvinyl ester polymer, copolymers thereof, and a mixture of at least one polyalkyl(meth)acrylate with one or more of the group consisting of polystyrene, polyacrylonitrile, polycarbonate, and polysulfone;
• the material containing at least one structural element (A) which is the ester group of the acrylate or vinylester polymer, and
• (b) a linker coupled to a pharmaceutically or physiologically active substance, the linker selected from the group consisting of a (poly)alkylene glycol, a (poly)alkylene imine, a (poly)alkylene amine, a polyoxazilin and a (poly)alkylene sulfide,
• wherein the linker is attached to the structural element (A) on the surface of the plastic material by a hydrogen bond which cannot be reversed by pH values in the range of 2 to 13 or temperatures up to 60° C., wherein the target substance is bound, cleaved or otherwise modified by the coupled substance.

A kit comprising an interactive system for carrying out a method of binding, cleaving, or otherwise modifying a target substance in a liquid comprising contacting a liquid with an interactive system comprising:

• (a) a surface of a plastic material selected from the group consisting of a poly(meth)acrylate polymer, a polyvinyl ester polymer, copolymers thereof, and a mixture of at least one polyalkyl(meth)acrylate with one or more of the group consisting of polystyrene, polyacrylonitrile, polycarbonate, and polysulfone;
• the material containing at least one structural element (A) which is the ester group of the acrylate or vinylester polymer, and (b) a linker coupled to a pharmaceutically or physiologically active substance, the linker selected from the group consisting of a (poly)alkylene glycol, a (poly)alkylene imine, a (poly)alkylene amine, a polyoxazilin and a (poly)alkylene sulfide,
• wherein the linker is attached to the structural element (A) on the surface of the plastic material by a hydrogen bond which cannot be reversed by pH values in the range of 2 to 13 or temperatures up to 60° C., wherein the target substance is bound, cleaved or otherwise modified by the coupled substance;
• wherein the kit comprises items selected from the group consisting of suitable reagents, buffer solutions, reaction vessels, packaging and combinations thereof.

A method for treating a liquid comprising placing the liquid in contact with an interactive system comprising:

• (a) a surface of a plastic material selected from the group consisting of a poly(meth)acrylate polymer, a polyvinyl ester polymer, copolymers thereof, and a mixture of at least one polyalkyl(meth)acrylate with one or more of the group consisting of polystyrene, polyacrylonitrile, polycarbonate, and polysulfone;
• the material containing at least one structural element (A) which is the ester group of the acrylate or vinylester polymer, and
• (b) a linker coupled to a pharmaceutically or physiologically active substance, the linker selected from the group consisting of a (poly)alkylene glycol, a (poly)alkylene imine, a (poly)alkylene amine, a polyoxazilin and a (poly)alkylene sulfide,
• wherein the linker is attached to the structural element (A) on the surface of the plastic material by a hydrogen bond which cannot be reversed by pH values in the range of 2 to 13 or temperatures up to 60° C.;
• and then separating the liquid after treatment.

The method for the treatment of an ailment selected from the group consisting of metabolic diseases, coagulation defects, viral infections, bacterial infections, mycotic infections, parasitic infections and malignant diseases comprising administering to a patient to be treated an interactive system comprising:

• (a) a surface of a plastic material selected from the group consisting of a poly(meth)acrylate polymer, a polyvinyl ester polymer, copolymers thereof, and a mixture of at least one polyalkyl(meth)acrylate with one or more of the group consisting of polystyrene, polyacrylonitrile, polycarbonate, and polysulfone;
• the material containing at least one structural element (A) which is the ester group of the acrylate or vinylester polymer, and
• (b) a linker coupled to a pharmaceutically or physiologically active substance, the linker selected from the group consisting of a (poly)alkylene glycol, a (poly)alkylene imine, a (poly)alkylene amine, a polyoxazilin and a (poly)alkylene sulfide,
• wherein the linker is attached to the structural element (A) on the surface of the plastic material by a hydrogen bond which cannot be reversed by pH values in the range of 2 to 13 or temperatures up to 60° C.